Synopsis: This course will cover the biology and statistics of the analysis of complex traits (those whose phenotypes are determined by the interaction between variation at a number of genes coupled with environmental variation). This covers just about every trait of interest in evolution, ecology, medicine, and applied breeding. The focus will be on teaching the basic statistical machinery while focusing on biologically interesting questions. While the main focus will be on evolutionary applications, many of the topics will also be of interest to those working in medicine, genomics, and applied breeding.
Instructor: Bruce Walsh, jbwalsh@u.arizona.edu
Credits: Three Units
Time/location: Tuesday/Thursday 9:30 - 10:45 LSS 340
Class Text: Genetics and Analysis of Quantitative Traits, Lynch and Walsh, 1998
Grading: Problems sets and class assignments.
Prerequisites: Course in Genetics, Statistics
| Date | Lecture number | Topic | Readings/handouts | Additional Notes on advanced topics |
| 11 Jan (Thursday) | 1 | Basic Statistical Machinery | pdf of Lecture 1 notes |
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| 16 Jan (Tuesday) | 2 | Linear Algebra and Linear Models | pdf of Lectures 2-3 notes | |
| 18 Jan (Thursday) | 3 | Linear Algebra and Linear Models | pdf of Lectures 2-3 notes | |
| 23 Jan (Tuesday) | 4 | Basic Concepts in Mendelian, Population and Quantitative Genetics | pdf of Lecture 4 notes | |
| 25 Jan (Thursday) | 5 | Resemblance Between Relatives | pdf of Lecture 5 notes | |
| 30 Jan (Tuesday) | 6 | Basic Designs for Estimation of Genetic Parameters | pdf of Lectures 6-7 notes | |
| 1 Feb (Thursday) | 7 | Basic Designs for Estimation of Genetic Parameters | pdf of Lectures 6-7 notes | |
| 6 Feb (Tuesday) | 8 | Major Genes, Polygenes, and QTLs | pdf of Lecture 8 notes | |
| 8 Feb (Thursday) | No Class | |||
| 13 Feb (Tuesday) | 9 | QTL Mapping | pdf of Lectures 9-10 notes | |
| 15 Feb (Thursday) | 10 | QTL Mapping | pdf of Lectures 9-10 notes | |
| 20 Feb (Tuesday) | No Class | |||
| 22 Feb (Thursday) | No Class | |||
| 27 Feb (Tuesday) | 11 | QTL Mapping | ||
| 1 Mar (Thursday) | 12 | QTL Mapping | ||
| 6 Mar (Tuesday) | 13 | QTL Mapping | ||
| 8 Mar (Thursday) | 14 | Short-term Selection Response | ||
| 13 Mar (Tuesday) | Spring break! | |||
| 15 Mar (Thursday) | Spring break! | |||
| 20 Mar (Tuesday) | 15 | Short-term Selection Response | ||
| 22 Mar (Thursday) | 16 | Short-term Selection Response | ||
| 27 Mar (Tuesday) | 17 | Long-term Selection Response and Selection Limits | ||
| 29 Mar (Thursday) | 18 | Long-term Selection Response and Selection Limits | ||
| 3 Apr (Tuesday) | 19 | Individual Fitness and Measures of Univariate Selection | ||
| 5 Apr (Thursday) | 20 | Individual Fitness and Measures of Univariate Selection | ||
| 10 Apr (Tuesday) | 21 | Genetic Correlations and Multivariate Selection Response | ||
| 12 Apr (Thursday) | 22 | Genetic Correlations and Multivariate Selection Response | ||
| 17 Apr (Tuesday) | 23 | Measuring Multivariate Selection | ||
| 19 Apr (Thursday) | 24 | Measuring Multivariate Selection | ||
| 24 Apr (Tuesday) | 25 | Measuring Multivariate Selection | ||
| 26 Apr (Thursday) | 26 | Quantitative Analysis of Regulatory Variation | ||
| 8 May (Tuesday) | 27 | Quantitative Analysis of Regulatory Variation |