Optional Problems in Selection

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 since 26 Nov 1999 

  1. What is the equilibrium allele frequency of a lethal recessive when the mutation rate (to this allele) is 10-4? What is the expected frequency of such diseased individuals in the population at birth (assuming lethality occurs after birth)?

  2. What are the answers for question one with a lethal dominant?

  3. Consider one locus with two alleles (A and a) with fitnesses WAA = 11, WAa = 9, Waa = 7. If Freq(A) = 0.2, what is Wbar (mean population fitness)? WA? Wa? What is the new frequency of allele A after one generation of selection?

  4. Consider one locus with five alleles, with
    alleles A1 A2 A3 A4 A5
    marginal fitnesses 1 5 2 4 3
    allele frequencies 0.1 0.2 0.4 0.2 0.1

    What is Wbar? What is the change in allele frequency for allele 1? Allele 3? Allele 5?

  5. Consider one locus with two alleles (A,a) with fitnesses WAA = 5, WAa = 10, Waa = 7. What are the equilibrium frequencies of A? of a? What is Wbar at equilibrium?