Study guide for Exam 1

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since 25 September 1998

Disclaimer: This is to sever as a rough guide only. Material left off this list can still be asked!!!

• P(A,B) = P(A | B) P(B);
• P(A | B) = P(A ,B) / P(B)
• Poisson formula, P(k) = m^k e^-m /k!,
• All, none terms from binomial, P(0) = (1-p) ⁿ, P(n) = pⁿ
• c₁₃ = c₁₂ + c₂₃ - 2c₁₂ c₂₃

• And, Or rules.
• How and when to use the Poisson, Binomial and Geometric distributions.
• How to compute the relative risk of a disease
• Sex-linkage.
• Sex determination in mammals vs. insects.
• Dosage compensation in mammals vs. insects.
• Behavior of ABO blood groups.
• Genetics of color vision.
• Linkage.
• Be able to compute expected frequencies of parental and recombinant gametes.
• Be able to determine the linkage phase of parents.
• Be able to compute the expected frequency of double recombinants.
• Be able to carry out a Three-Point Testcross.
• Be able to compute Interference and Coefficient of Coincidence.
• Map distances vs. recombination frequencies.
• Genetics vs. physical maps.
• Why do we use mapping functions?
• How can the genetic map shrink and/or expand relative to the physical map?
• What is the logic behind family and sib-analysis methods for mapping QTLs?
• Be able to compute gene-centromere recombination frequency using ordered tetrads/octads.
• Be able to compute recombination frequencies using tetrad data.
• Why is maximum frequency of second -division segregation = 2/3?
• What are the consequences of Somatic versus germline mutation?
• Loss-of-function, leaky, gain of function mutations.
• Know how to estimate the mutation rate with N cultures, each with n cells.
• Retinoblastoma and mitotic crossingover.
• Behavior of Pericentric vs. paracentric inversions at meiosis.
• Behavior of translocation heterozygotes at meiosis.
• Adjacent vs. alternate segregation.

• Theodor Boveri
• Calvin Blackwell Bridges
• Elinor Carothers
• Gregor Mendel
• Walter Sutton

• Acrocentric
• Adjacent segregation
• Allopolyploids
• Alternate segregation
• aneuploid
• Autopolyploids
• auxotrophic
• Barr body
• Bilateral gynandromorphs
• Candidate locus
• Chiasma
• Codominance
• Coefficient of Coincidence
• Conditional mutations
• Coupling
• dicentric bridge
• Dioecious
• Disease susceptibility
• Down's syndrome
• Edward's syndrome
• Epistasis
• euploid
• Expressivity
• first -division segregation
• Genetic map
• hemizygous
• Heterogametic sex
• Homogametic sex
• Imprinting
• Incomplete dominance
• Interference
• Klinefelter's syndrome
• Metacentric
• Mitotic crossing-over
• Monoecious
• monosomic
• Nondisjunction
• Nonparental ditypes
• nullisomic
• oncogenes
• Overdominance
• paracentric inversions
• Parental ditypes
• parental gametes
• Patau's syndrome
• Penetrance
• Pericentric inversions
• Phenocopies
• physical map
• Pleiotropy
• Prader-Willi syndrone
• proto-oncogenes
• prototrophic
• pseudodominance
• Quantitative Trait loci
• recombinant gametes
• Recombination frequency
• Replusion
• restrictive vs. permissive conditions
• reversion
• second -division segregation
• synteny
• Telocentric
• Tetratypes
• trisomic
• Turner's syndrome
• Wild type