Lecture 25: Using Cloned Genes for Disease Screening

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since 4 October 1999

(version 24 September, 1999)

Cloned genes can be used in

(i) Direct detection. e.g., sickle-cell anemia, cystic fibrosis and Huntington's disease:

Sickle cell anemia:

b. Indirect detection e.g., for hemophilia A

Disease allele can be detected:

(i) after birth

(ii) in utero e.g., by amniocentesis

(iii) in preimplantation embryos

Some ethical issues to consider:

(i) Who has the right to the information?

(ii) What characters should be selected for or against?

(iii) Who should pay for expensive technology?