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since 26 Feb 1996 |

- Suppose 25 out of 750 students are redheads. What is frequency of redheads? If a random student is choosen, what is the probability they are a redhead?
- Consider a locus with two alleles,
**A**and**a**. If the frequency of**AA**is 0.25, what is the frequency of**A**under Hardy-Weinberg? - If the genotypes
**AA**,**Aa**, and**aa**have frequencies 0.5, 0.25, and 0.25 (respectively), what are p = freq(**A**)? q = freq (**a**)? After a single generation of random mating, what is the expected frequency of**AA**? of**Aa**? of**aa**? - Consider a locus with 12 alleles,
**A**_{1},**A**_{2}, ... ,**A**_{12}. What is the frequency of allele**A**_{1}if we know that freq(**A**_{1}**A**_{1}) = 0.10, and that the frequency of all heterozygote genotypes containing**A**_{1}is 0.40. Under the assumption of Hardy-Weinberg, what is the expected frequency of**A**_{1}**A**_{1}? Of any heterozygote involving**A**_{1}? - Assume Hardy-Weinberg and a locus with two alleles. If p = freq(
**A**), what fraction of all copies of allele**a**. are found in heterozygotes? - Assume that
**A**is completely dominant over**a**, with**aa**individuals displaying a disease while all others are normal. An individual of genotype is**Aa**is called a carrier as they appear normal, but can have offspring with the disease. (i) Under Hardy-Weinberg, if freq(**a**) = 0.001 what fraction of all copies of**a**are in carriers? (ii) What fraction of all**aa**individuals had both parents as carriers (i.e., neither parent displays the trait). - If the genotypes
**AA**,**Aa**, and**aa**have fitnesses 1: 1.5: 1.6, what allele is fixed? - The genotype
**aa**is lethal and yet the population has an equilibrium frequency for**a**of .40. If the fitness of**Aa**is 1, what is the fitness of the**AA**genotype? - Suppose a population starts out with 10,000
**AA**individuals, 20,000**Aa**, and 10,000**aa**. (i) What is the frequency of**A**? Is this population in Hardy-Weinberg? (ii) Suppose all**aa**individuals die before reproducing, while (on average)**AA**and**Aa**individuals leave the same number of offspring. What are the fitnesses of these three genotypes? (iii) Following selection, what fraction of the surviving adults are**AA**?**Aa**?**aa**? What is the frequency of**a**? (iv) If these surviving adults mate at random, what is the frequency of**aa**in the next generation (before selection acts).**Solutions**